It's not fun anymore for developers. Of course it isn't, but do normal users care? I can't say I've enjoyed using twitter any less since they introduced the API limit.
I can say I've all but stopped using twitter altogether since their purchase/bastardization of tweetdeck. That client was nearly perfect.. multiple networks support, persistent searches...
Twitter is not important enough for me to have to run a separate application for it.
Echofon for OSX is no longer functional since API 1.0 was deprecated.
I've moved to another native client, but as a user who likes to see multiple avenues for engineers to subsist (i.e. not just working for bigco), it's saddening to see.