Assuming somehow I got to that stage, that's the point I would realize there is very good chance I will be killed or kidnapped if I don't do what the people that are observing me expect. I would try to conceive a plan to leave with the empty suit case from the hotel but ditch it shortly before boarding a flight to US. Still at that point I would fear retribution later in US and because of that I might decide that the best course of action is to go along sadly.

leave a suitcase full of coke in a hotel room reserved in your name?

Yes, because your claim you thought it was just a dumb empty suitcase will be very believable. You forgot it because (A) it was not your bag and (B) it was not valuable, so it was easy to forget.

Unless they find evidence that you opened it, like your fingerprints where they shouldn't be- or they get you to crack in interrogation.

Better to be honest and call the police on yourself so-to-speak, or at least destroy the drugs before you leave the bag.