Sequentially? Yes. Simultaneously? Rare. Doxorubicin and cisplatin, has been done, but keytruda was quite interesting when it started to do clinical trials in combination with various chemos so that the FDA would approve it. My late-wife's oncologist was hesitant on combining anything, but I kept pushing for pembro plus anything.
But this was also systemically applied, these new ADCs are targeted, much stronger with combination payloads. Sadly, not as effective for harsher cancers like triple-negative BC.
This doesn't track my experience. I have Ewing's Sarcoma, and my first regimen involved 5 agents: Doxorubicin, Vincristine, Cytoxan, Ifofsfomide, and Etoposide. This [1] appears to be the same plan I used. When that failed, I had a second regimen with Vincristine, Irinotecan, and Temozolomide. After that failed, I had Irinotecan and Trabectidin, followed by Doxil, followed by, Cytoxan and Topotecan, followed by high dose Ifofsfomide. So only two of the treatments I received were single agent, but maybe it depends on the cancer.
