Depends- for example, duirng the time that Google started up, I was in grad school with a great deal of support for starting biotech companies, but when I looked... even the geniuses were struggling because at the time, biotech companies could take a decade or more to be profitable or fail. It was clear, as we were exiting the late 90s dot com crash that the economy and money for tech was going to come back, and companies that took advantage of rapidly increasing specs on cheap machines (versus buying expensive Suns, DECs, or SGIs) were going to be able to scale to immense amounts of traffic, and deliver ads for profit.