Yes, one of them is NOLOH (http://www.noloh.com). It's actually an acronym for "Not One Line Of HTML". You can of course use HTML/CSS/JavaScript, but you never have to, and if you do there's extensive handling to allow you to do things you wouldn't be able to normally do in straight up JavaScript, such as handling race conditions, dynamic instantiations, and related situations.

Disclaimer: I'm a co-founder of NOLOH