| 1. | | Drug trio found to block tumour resistance in pancreatic cancer in mouse models (drugtargetreview.com) |
| 271 points by axiomdata316 8 days ago | 150 comments |
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| 2. | | Airfoil (2024) (ciechanow.ski) |
| 531 points by brk 9 days ago | 60 comments |
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| 3. | | Proof of Corn (proofofcorn.com) |
| 476 points by rocauc 14 days ago | 307 comments |
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| 4. | | The best things and stuff of 2025 (fogus.me) |
| 415 points by adityaathalye 45 days ago | 98 comments |
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| 5. | | Auto-grading decade-old Hacker News discussions with hindsight (karpathy.bearblog.dev) |
| 686 points by __rito__ 58 days ago | 270 comments |
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| 6. | | Claude Advanced Tool Use (anthropic.com) |
| 673 points by lebovic 74 days ago | 266 comments |
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| 7. | | Claude says “You're absolutely right!” about everything (github.com/anthropics) |
| 773 points by pr337h4m 5 months ago | 533 comments |
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| 8. | | Ask HN: How can ChatGPT serve 700M users when I can't run one GPT-4 locally? |
| 574 points by superasn 6 months ago | 365 comments |
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| 9. | | CARA – High precision robot dog using rope (aaedmusa.com) |
| 1073 points by hakonjdjohnsen 6 months ago | 182 comments |
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| 10. | | The bitter lesson is coming for tokenization (lucalp.dev) |
| 303 points by todsacerdoti 7 months ago | 160 comments |
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| 11. | | Ask HN: What's the most creative 'useless' program you've ever written? |
| 296 points by reverseCh on Oct 20, 2024 | 405 comments |
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| 12. | | Client-side filtering of private data is a bad idea (mjg59.dreamwidth.org) |
| 141 points by ramimac on Aug 19, 2024 | 49 comments |
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| 13. | | Show HN: PGlite – in-browser WASM Postgres with pgvector and live sync (pglite.dev) |
| 509 points by samwillis on Aug 12, 2024 | 108 comments |
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| 14. | | Susan Wojcicki has died (twitter.com/sundarpichai) |
| 721 points by grandmczeb on Aug 10, 2024 | 452 comments |
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| 15. | | XLSTMTime: Long-Term Time Series Forecasting with xLSTM (arxiv.org) |
| 231 points by beefman on July 16, 2024 | 53 comments |
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| 16. | | Polars (pola.rs) |
| 981 points by tosh on Jan 8, 2024 | 386 comments |
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| 17. | | Mixtral 8x7B: A sparse Mixture of Experts language model (arxiv.org) |
| 359 points by ignoramous on Jan 9, 2024 | 150 comments |
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| 18. | | Concept sliders: LoRA adaptors for precise control in diffusion models (baulab.info) |
| 153 points by billconan on Dec 12, 2023 | 57 comments |
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| 19. | | Reflecting on 18 Years at Google (hixie.ch) |
| 2213 points by whiplashoo on Nov 22, 2023 | 1040 comments |
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| 20. | | On a great interview question (behdadesfahbod.medium.com) |
| 250 points by behdad on April 12, 2023 | 456 comments |
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| 21. | | New health insurance “transparency data” looks suspiciously wrong (dolthub.com) |
| 446 points by sl-dolt on March 28, 2023 | 162 comments |
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| 22. | | Ask HN: How are you using GPT to be productive? |
| 629 points by yosito on March 25, 2023 | 735 comments |
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| 23. | | The developer job market is insane (reddit.com) |
| 134 points by csomar on March 22, 2023 | 260 comments |
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| 24. | | Prostate cancer could be treated by destroying tumors with electric currents (telegraph.co.uk) |
| 577 points by rmason on March 17, 2023 | 107 comments |
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| 25. | | GPT-4 (openai.com) |
| 4091 points by e0m on March 14, 2023 | 2507 comments |
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| 26. | | Joint statement by the Department of the Treasury, Federal Reserve, and FDIC (treasury.gov) |
| 1699 points by FormerBandmate on March 12, 2023 | 2512 comments |
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| 27. | | The Summly deal makes no sense (philosophically.com) |
| 379 points by thomseddon on March 26, 2013 | 251 comments |
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| 28. | | Llama.cpp: Port of Facebook's LLaMA model in C/C++, with Apple Silicon support (github.com/ggerganov) |
| 989 points by mrtksn on March 10, 2023 | 284 comments |
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| 29. | | ChatGPT generated a puzzle game (puzzledpenguin.substack.com) |
| 486 points by puzzledpenguin on March 6, 2023 | 243 comments |
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| 30. | | Ask HN: What are the best advanced computer science courses online? |
| 345 points by st1x7 on Dec 1, 2020 | 89 comments |
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| More |
